Edward married Dorothy Jerningham in 1537. Dorothy was born about 1515 in Kent, England, United Kingdom; died before 1552. [Group Sheet] [Family Chart]

1. Jane Izaacke was born in 1544 in Patrixbourne, Canterbury, Kent, England; was christened in 1544 in Patrixbourne, Canterbury, Kent, England; and died.
2. Thomas Isaac was born in 1545 in Canterbury, Kent, England; died in 1592 in Canterbury, Kent, England.
3. Marjorie Isaac was born before 1546 in Well Court, Manor of Well, Kent, England; died before 1572 in England, Unitd Kingdom.
4. Mary Isaacke was born in 1549 in Patrixbourne, City of Canterbury, Kent, England; died on 11 Jun 1613 in London Saint Bride's Church Fleet Street, Middlesex, England; was buried on 11 Jun 1613 in London Saint Bride's Church Fleet Street, Middlesex, England.