Charles married Mary Ann Bulkeley Rogers on 21 Nov 1830 in Colchester, Connecticut. Mary (daughter of Dr Howell Rogers and Sarah Bulkeley) was born on 9 Oct 1809 in Colchester, New London, Connecticut, United States; died in 1870 in Avon, Livingston, New York, United States. [Group Sheet] [Family Chart]

1. Sarah Esther Isham was born on 6 Nov 1831 in Colchester, Connecticut; died on 15 Nov 1831.
2. Charles Rogers Isham was born on 15 Dec 1834 in Colchester, New London, Connecticut, United States; died in Oct 1908; was buried in 1908 in Covington, Wyoming, New York, United States.
3. Henry H. Isham was born on 22 Nov 1836 in Colchester, New London, Connecticut, United States; died on 21 Nov 1906; was buried in Coffeyville, Montgomery, Kansas, United States of America.
4. John T. Isham was born in 1839 in Avon, Livingston, N .. Y.; and died.
5. Mary Ann Isham was born on 20 May 1842 in Avon, Livingston, New York; and died.
6. Francis Napoleon Isham was born in 1843 in Avon, Livingston, N .. Y.; and died.
7. Alfred Huntington Isham, Sr was born in Jul 1846 in New York, United States; died on 27 Nov 1910 in Manhattan, New York City, New York, United States.